Serena Williams will face Danka Kovinic of Montenegro in her first round match at the US Open on Monday following the draw for the tournament.
Williams, the 23-time Grand Slam title winner who has hinted she will make the event her farewell tournament, is in the same quarter of the draw as second seed Anett Kontaveit of Estonia. The 40-year-old American superstar, whose first Grand Slam title came at the 1999 US Open, would meet Kontaveit in the second round if both win their opening matches at the year's final Grand Slam event.
The USTA announced later Thursday that all women's matches in Williams's half of the draw will be scheduled for Monday. Williams, who is one title shy of the all-time record 24 Slam crowns won by Margaret Court, could have quite a path to the final were she to make a shock run on the Flushing Meadows hardcourts.
She could face Canada's 14th-seeded Leylah Fernandez, a 19-year-old who was last year's US Open runner-up, in the fourth round and Tunisia's Ons Jabeur, this year's Wimbledon runner-up, in the quarter-finals.
The winner from Kontaveit's quarter of the draw could meet Greek third seed Maria Sakkari or Romania's seventh-seeded Simona Halep in the semi-finals. The other half of the bracket features top seed Iga Swiatek of Poland, this year's French Open champion, and Spanish fourth seed Paula Badosa.
Swiatek could meet US eighth seed Jessica Pegula in a quarter-final while Badosa could face sixth seed Aryna Sabalenka.
Japan's Naomi Osaka, a four-time Grand Slam champion, is also in Badosa's quarter of the draw.
She would meet defending champion Emma Raducanu, the 11th seed from Britain, in a third-round showdown and Sabalenka in the round of 16. Victoria Azarenka, a two-time Australian Open winner, could meet Badosa in the third round.
Venus Williams, a seven-time Grand Slam champion, could meet Sabalenka in the third round, meaning she could only face younger sister Serena in a US Open final, likely meaning the siblings have faced each other for the final time in a major singles draw.
Serena indicated in interviews earlier this month that she is ready to move on with other areas of her life, including possibly having a second child.