Southampton booked an FA Cup fifth round tie against Liverpool with a 3-0 win over Watford on Tuesday, while Coventry's 4-1 victory against Sheffield Wednesday secured a date with history makers Maidstone.
Saints forward Sekou Mara struck twice in the fourth round replay at St Mary's to secure the prized trip to Premier League leaders Liverpool. The Championship high-fliers, unbeaten in their last 24 games in all competitions, took the lead when Che Adams teed up Mara in the 52nd minute. Mara doubled his tally six minutes later as the French youngster struck for the fifth time in his last nine appearances.
Adams completed the comfortable dismissal of second-tier Watford with a clinical finish 14 minutes from full-time.
Coventry will host National League South side Maidstone after Callum O'Hare's double saw off Wednesday in another all-Championship replay.
It was the third meeting between Coventry and Wednesday in just 17 days. Palmer opened the scoring in the third minute before Mark Robins' men were pegged back by Bailey Cadamarteri's equaliser.
Three goals in eight second-half minutes, including two from O'Hare and one from Haji Wright, ensured Coventry will host the lowest-ranked side left in the competition.
Maidstone became the first club from outside the top five tiers of English football to reach the FA Cup fifth round since Blyth Spartans in 1978 when they beat Ipswich 2-1 at Portman Road in one of the great recent cup upsets.