Liverpool boss Arne Slot faces his first major test with a trip to Manchester United, while Newcastle and Tottenham also face off on Sunday hoping to dispel early season doubts over their credentials for a top-four finish.
Slot has made a perfect start to the daunting task of succeeding Jurgen Klopp with two wins from his opening two Premier League games without conceding.
His first chance to seriously impress the Liverpool support comes at one of Klopp's least favorite grounds as English football's two most successful clubs face off at Old Trafford.
Despite Liverpool largely enjoying the superior league position during Klopp's near nine-year reign, he won just two of his 11 away games to United.
That run included a 4-3 FA Cup quarterfinal exit and 2-2 Premier League draw last season that precipitated a Liverpool collapse in his final few months in charge.
Yet the pressure is arguably even more on the Dutch manager in the other dugout.
Erik ten Hag was backed by those at the top of United's new sporting structure at the end of last season despite finishing eighth - the club's worst ever Premier League performance.
Hope of a new dawn for the Red Devils has been diminished in the opening weeks of the new campaign.
Joshua Zirkzee's late winner on his debut at least ensured a winning start against Fulham, but a 2-1 defeat to Brighton last weekend had many of the same hallmarks that have seen United struggle previously under Ten Hag.
Another damaging defeat at home to fierce rivals will put the former Ajax boss' future back on the agenda just three games into the new season.
Meanwhile, Tottenham's last two trips to St James' Park have resulted in 6-1 and 4-0 thrashings by the Magpies.
Both sides have four points from their opening two games but have a point to prove to further their ambitions of returning to the Champions League next season.
Newcastle battled past newly-promoted Southampton 1-0 with 10 men on the opening weekend but were lucky to emerge with a point from a 1-1 draw at Bournemouth.
Eddie Howe's men also needed penalties to get past Nottingham Forest in the League Cup in midweek and there is frustration on Tyneside at their inability to strengthen in the transfer market.
Newcastle have the financial might of the Saudi sovereign wealth fund behind them but have been restricted by the need to meet profit and sustainability rules.
Tottenham cruised past Everton 4-0 last weekend but a 1-1 draw at Leicester exposed familiar vulnerabilities for Ange Postecoglou's men on the road as a combination of missed chances and careless defending cost them all three points.
