Hamas-run Gaza's health ministry said Monday Israeli forces were bombarding the last partially functioning hospital in the territory's north, as Israel formally notified the UN it is cutting ties with the main aid agency for Palestinians.
Vowing to stop Hamas from regrouping in northern Gaza, Israel launched a major air and ground assault nearly a month ago, a year into its war against the Islamists.
Rescuers and UN agencies say hundreds of people have been killed and the area has been left desperately short of essential supplies.
Gaza's health ministry said Israeli forces were "continuing to violently bombard and destroy Kamal Adwan Hospital".
Hospital director Hossam Abu Safieh said in a statement the situation was "catastrophic", with several staff injured.
"We do not understand the purpose behind this bombing that is targeting the hospital."
World Health Organization chief Tedros Adhanom Ghebreyesus said six child patients were injured in the strike on the hospital, which he described as "appalling".
Israel's military said it was checking the report.
Separately, it said troops "are continuing to operate against terrorist infrastructure and operatives in the northern and central Gaza Strip".
- 'No alternative' -
Earlier Monday Israel issued formal notification that ties with UNRWA, the UN agency supporting Palestinian refugees, would be cut after lawmakers voted to ban the organisation vital to Palestinians in the occupied territories.
The ban sparked global condemnation and came after the United States in mid-October warned Israel it could withhold some of its billions of dollars in military assistance unless it improves aid delivery to Gaza within 30 days.
"There is simply no alternative to UNRWA," WHO chief Tedros said in a video posted on X Monday, adding that the "ban will not make Israel safer".
Israel has accused a dozen of UNRWA's roughly 13,000 employees in Gaza of involvement in the October 7, 2023 attack by Hamas which triggered the Gaza war.
"On the instruction of Foreign Minister Israel Katz, the ministry of foreign affairs notified the UN of the cancellation of the agreement between the State of Israel and UNRWA," a ministry statement said.
Katz was quoted as saying UNRWA was "part of the problem in the Gaza Strip and not part of the solution".
Hamas's October 7 attack resulted in the deaths of 1,206 people, mostly civilians, according to an AFP tally of Israeli official figures.
Israel's retaliatory campaign has killed 43,374 people in Gaza, most of them civilians, according to Gaza health ministry figures which the United Nations considers to be reliable.
- 'Backbone' -
The letter sent by Israel to the president of the UN General Assembly, dated November 3 and seen by AFP, said the ban would come into effect "following a three-month period".
Jonathan Fowler, an UNRWA spokesman, told AFP the move would be disastrous.
"If this law is implemented, it would be likely to cause the collapse of the international humanitarian operation in the Gaza Strip -- an operation of which UNRWA is the backbone," Fowler said.
UNRWA chief Philippe Lazzarini wrote on X that an average of just 30 trucks daily were allowed into Gaza last month.
The UN has said around 500 trucks entered every day before the war.
Gazans told AFP they were alarmed by Israel's move.
Abdul Karim Kallab from the southern city of Khan Yunis said the people "depend almost entirely on aid coming from abroad, especially from UNRWA", and without it they would starve.
Hamas said it showed that Israel was a "rogue state".
But Katz said aid would continue entering Gaza "in a manner that does not harm the security of the citizens of Israel".
UNRWA fired nine employees after an internal probe found they "may have been involved in the armed attacks of 7 October".
The UN General Assembly, which originally set up UNRWA, will hold a session on Wednesday, scheduled before Israel sent the letter.
Gaza's civil defence chief Mahmud Bassal said Monday that "there is a severe blockade on medicine, water, and food" in north Gaza and more than 1,300 people have been killed in Israel's operation there.
- 'Systematic destruction' -
Hamas, meanwhile, said it had held talks with rival Palestinian faction Fatah in Cairo on "the war on Gaza and pathways for national action", adding such talks would continue.
US Secretary of State Antony Blinken blamed Hamas for rejecting a temporary truce as he also pressed Israel again to allow more aid into Gaza.
Blinken said in a telephone call with Egypt's Foreign Minister Badr Abdelatty that "Hamas has once again refused to release even a limited number of hostages to secure a ceasefire and relief for the people of Gaza", according to a State Department statement.
During the October 7, 2023 attack on Israel, Palestinian militants seized 251 hostages, of whom 97 are still in Gaza. The Israeli military says 34 of them are dead.
Since late September, Israel has broadened the focus of its war to Lebanon with air strikes and ground troops after nearly a year of tit-for-tat cross-border exchanges with Iran-backed Hezbollah.
Israel says it is targeting Hezbollah infrastructure in a bid to push it back from the frontier, allowing residents to return to their homes in northern Israel.
Footage verified by AFP Monday showed massive detonations in the southern Lebanese border village of Mais al-Jabal, where the mayor accused Israel of "systematic destruction".
The war in Lebanon has killed more than 1,940 people since September 23, according to an AFP tally of Lebanese health ministry figures.
Hezbollah said it again fired rockets at Israel's northern city of Safed on Monday.
Israeli jets attacked several areas of southern Lebanon, Lebanon's official National News Agency (NNA) reported.
Iran-aligned groups in Yemen, Iraq and Syria have also been drawn into the conflict, and Iran and Israel have attacked each other directly, heightening fears of a wider conflagration.
Gaza rescuers say displaced Palestinians among 13 dead in Israel strikes
Gaza civil defence agency said on Tuesday that at least 13 people, including some living in tents for displaced Palestinians, were killed in Israeli air strikes overnight.
Four people were killed when an Israeli missile hit the home of the Shurafa family in eastern Gaza City, civil defence spokesman Mahmud Bassal told AFP.
Three people were killed and several wounded when a tent housing Palestinians displaced by the war was hit by an Israeli missile in the east of Khan Yunis city, Bassal said.
Another tent housing displaced people in Deir el-Balah in central Gaza was also hit by an Israeli air strike overnight, killing at least four people, he added.
Two other people were killed in separate incidents, Bassal said.
The Israeli military, meanwhile, said its forces were continuing their land and air assault in northern Gaza, where the civil defence says hundreds have been killed since October 6, when the military launched the offensive.
"Over the past day, IDF (military) troops in the area of Jabalia eliminated dozens of terrorists during close-quarters encounters and aerial strikes," the military said in a statement.
Several militants were also killed in central Gaza and in the area of Rafa in the south of the territory, the military added.
Israel has been waging a month-long military offensive in northern Gaza, which it says is aimed at preventing Hamas militants from regrouping.
